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Revista Colombiana de Gastroenterologia

Print version ISSN 0120-9957


GUERRERO BERMUDEZ, Camila; VELEZ MARIN, Mariana  and  RESTREPO GUTIERREZ, Juan Carlos. Cholangiocarcinoma in patients with primary sclerosing cholangitis. Rev Col Gastroenterol [online]. 2018, vol.33, n.3, pp.285-291. ISSN 0120-9957.

Primary sclerosing cholangitis (PSC) is an uncommon inflammatory disease that affects the bile ducts to produce cholestasis. Currently, the only treatment available is management of symptoms with ursodeoxycholic acid and liver transplantation. In addition to its relation to long-term cirrhosis, its natural history has an important association with cholangiocarcinoma (CCA), an aggressive neoplasia which is almost exclusive to this group of patients. Today CCA is the main cause of death of these patients, primarily due to the difficultly of diagnosis and the very limited treatment options.

This article discusses current ideas about this pathology and emphasizes the importance of appropriate screening with effective diagnostic tests (CA 19-9 and magnetic resonance cholangiopancreatography (MRC)) that help differentiate CCA from benign processes and can detect it in early stages when the probability of curative treatment is much greater.

Keywords : Primary sclerosing cholangitis; cholangiocarcinoma.

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