Resumo

ROJAS DEATENCIO, Alicia Elena et al. Relationship of Methylation of Tumor Suppressor Genes with Clinical Stage of Colorectal Cancer in Venezuelan Patients. Rev Col Gastroenterol [online]. 2019, vol.34, n.1, pp.1-9. ISSN 0120-9957.  https://doi.org/10.22516/25007440.225.

Colorectal cancer is a heterogeneous disease which involves hereditary and environmental factors. The inherited forms have genes which are responsible for increasing the tumor development in carriers. Environmental factors are considered responsible for many sporadic forms. The objective of this study was to analyze the methylation status of five genes involved in colorectal carcinogenesis and their relationships with the various clinical stages of these tumors. Our analysis revealed that the methylation status of the promoters of genes HMLH1, APC, P15, P16 and CDH1, considered to be among the earliest alterations in this process, ranged from 13.3% for HMLH1 to 56.6% for APC. In addition, epigenetic inactivation of APC and P16 genes could be responsible for the appearance and progression of tumors since inactivation was found in stage II patients. On the other hand, the APC and p15 gene were mutated in all stages of carcinogenesis, so they could be involved throughout the processes of initiation, invasion and metastasis. Finally, our results support using identification of methylation of suppressor genes since they identify epigenetic targets for development of new chemotherapy treatments. This is emerging as a strategy with great potential since epigenetic alterations are, in principle, potentially reversible.

Palavras-chave : Epigenetics; colorectal cancer; clinical evolution.

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