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Revista Colombiana de Gastroenterologia

Print version ISSN 0120-9957


LEDEZMA-MORALES, Mónica et al. Characterization of patients with chronic hepatitis C treated in a high complexity hospital in Medellín. Rev Col Gastroenterol [online]. 2019, vol.34, n.3, pp.249-260. ISSN 0120-9957.


Throughout the world hepatitis C (HepC) is a public health problem. Estimates for its prevalence in Colombia range from 0.5% to 1% but 2.1 % for patients over 50 years of age. The Hepatology Unit at the Hospital Pablo Tobón Uribe (HPTU) has been a benchmark for management of HepC in Medellín and Colombia for years.


To describe sociodemographic and clinical characteristics together with health outcomes of patients with chronic HepC who were treated at the HPTU between 2013 and 2018.

Materials and methods:

This is an observational, descriptive and retrospective study of patients with chronic HepC, treated between January 1, 2013 and March 31, 2018.


One hundred and eight patients were analyzed. The average age was 55.8 years (SD 13.7), 51.9% were men, and 78.7% belonged to the contributory health care scheme. Most frequently, the disease was transmitted by blood, and genotype 1 predominated in the group of patients analyzed. The effectiveness of interferon schemes was 46.9% while that of Direct-Acting Antivirals (DAA) was 94.6%. Adverse drug reactions were found in 68.2% of patients treated with interferon/ribavirin schemes but in only 25.9% of the patients treated with DAA.


In this group of patients treated at HPTU, DAA were safer and more effective than interferon/ribavirin schemes.

Keywords : Hepatitis C; Colombia; antivirals; interferons; direct action antivirals.

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