Abstract

GOMEZ ALDANA, Andrés José; TAPIAS, Mónica  and  LUQUEZ MINDIOLA, Adán. Diagnostic and therapeutic approach for cholestasis in the adult. Rev Col Gastroenterol [online]. 2020, vol.35, n.1, pp.76-86. ISSN 0120-9957.  https://doi.org/10.22516/25007440.375.

Cholestasis is one of the most frequent reasons for hepatology consultation. It is generated by altered synthesis, secretion or flow of bile through the biliary tract and is defined by elevated levels of enzymes such as alkaline phosphatase and gamma glutamyl transferase. In late stages, hyperbilirubinemia and clinical manifestations such as pruritus and jaundice develop. The diagnostic approach involves establishment of the reasons for elevated enzyme levels and determination of whether it is intrahepatic or extrahepatic. If it is intrahepatic, the source must be determined (hepatocytes, small bile ducts, or large caliber bile ducts). Treatment depends on the etiology, so accurate diagnosis is important. This review presents the pathophysiology and a diagnostic and therapeutic approach.

Keywords : Cholestasis; intrahepatic; extrahepatic.

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