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Revista colombiana de Gastroenterología
versión impresa ISSN 0120-9957versión On-line ISSN 2500-7440
Resumen
VELEZ-AGUIRRE, Juan David; LEPESQUEUR-GUILLEN, Lourdes y YEPES-BARRETO, Ismael. Nonalcoholic steatohepatitis: An emerging cause of cirrhosis in Colombia. Rev. colomb. Gastroenterol. [online]. 2022, vol.37, n.2, pp.136-143. Epub 22-Ago-2022. ISSN 0120-9957. https://doi.org/10.22516/25007440.783.
Introduction:
Cirrhosis of the liver is a significant cause of morbidity and mortality in Latin America; the increased prevalence of metabolic syndrome in our population could be changing the epidemiological profile of patients with advanced chronic liver disease.
Aim:
To characterize a group of patients with cirrhosis of the liver at an outpatient hepatology care center in Cartagena de Indias, Colombia, and determine the contribution of nonalcoholic steatohepatitis (NASH) as an etiological factor in this population.
Materials and methods:
Retrospective, cross-sectional, analytical study. All patients who attended the hepatology follow-up with a diagnosis of cirrhosis of the liver were in the six-monthly follow-up protocol that included screening for hepatocellular carcinoma (HCC) and esophageal varices.
Results:
346 patients were included, most were women (54.3 %). The first and second causes of cirrhosis were cryptogenic (35 %) and NASH (30.9 %), respectively, followed by viral hepatitis (17 %) and autoimmune diseases (9 %). Of these patients, 87.4 % were within categories A and B of the Child-Turcotte-Pugh score, and only 12.5 % (33 patients) were in stage C. Also, 60 % had at least one clinical decompensation, 38 % a history of variceal hemorrhage, and 4 % a diagnosis of HCC; 80.6 % of patients with NASH cirrhosis had diabetes, and 46.7 % were overweight.
Conclusion:
NASH cirrhosis is an emerging cause of advanced chronic liver disease in Colombia.
Palabras clave : Nonalcoholic fatty liver disease; cirrhosis of the liver; metabolic syndrome.