Abstract

GUTIERREZ, Víctor et al. Mixed Adenoneuroendocrine Carcinoma in the Ampulla of Vater: Case Report. Rev. colomb. Gastroenterol. [online]. 2023, vol.38, n.1, pp.100-105.  Epub June 08, 2023. ISSN 0120-9957.  https://doi.org/10.22516/25007440.903.

A mixed non-neuroendocrine neuroendocrine neoplasm is a mixed neoplasm with a neuroendocrine component combined with a non-neuroendocrine component. It has a low incidence and limited studies, but with evidence of being an aggressive entity associated with poor survival. We present the case of a 58-year-old woman admitted with clinical symptoms of abdominal pain in the left hypochondrium associated with generalized jaundice and feverish spikes with an imaging diagnosis of bile duct dilation secondary to distal choledocholithiasis. Endoscopic retrograde cholangiopancreatography (ERCP) was performed, finding a significant papilla with a neoplastic appearance, which was biopsied and histopathologically analyzed. The diagnosis of mixed carcinoma with a component of high-grade poorly differentiated neuroendocrine carcinoma and a component of mucinous carcinoma was confirmed. Therefore, we decided to schedule a pancreaticoduodenectomy.

Keywords : Adenoneuroendocrine carcinoma; ampulla of Vater; MINEN; MANEC.

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