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Revista colombiana de Gastroenterología
versión impresa ISSN 0120-9957versión On-line ISSN 2500-7440
Resumen
PARRA-IZQUIERDO, Viviana et al. Gastrointestinal and Hepatic Involvement in Primary Sjögren’s Syndrome: Case Report and Literature Review. Rev. colomb. Gastroenterol. [online]. 2023, vol.38, n.3, pp.338-347. Epub 18-Ene-2024. ISSN 0120-9957. https://doi.org/10.22516/25007440.918.
Sjögren’s syndrome is a systemic autoimmune disease characterized by dry eyes and mouth due to the involvement of exocrine glands. However, it can manifest with GI symptoms that cover a broad spectrum from esophageal and intestinal dysmotility, achalasia, hypochlorhydria, and chronic atrophic gastritis to pancreatic enzyme deficiency, biliary dysfunction, and liver cirrhosis, which varies in its clinical manifestations and is often associated with erroneous approaches. This article reviews the GI manifestations of Sjögren’s syndrome. It presents the case of a woman in her eighth decade of life with this syndrome. She showed asymptomatic hepatobiliary disease, documented abnormalities in liver profile tests, and a subsequent diagnosis of primary sclerosing cholangitis, for which she received initial treatment with ursodeoxycholic acid. During her condition, the patient has had three episodes of cholangitis, requiring endoscopic retrograde cholangiopancreatography with no findings of stones, with scant biliary sludge and discharge of purulent bile precipitated by her underlying liver disease. The association between Sjögren’s syndrome and primary sclerosing cholangitis is rare and calls for special consideration.
Palabras clave : Sjögren’s syndrome; sclerosing cholangitis; digestive system abnormalities; antinuclear antibodies; gastrointestinal diseases.