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Medicas UIS

Print version ISSN 0121-0319

Abstract

GARCIA RAMIREZ, Carlos Alberto et al. Her-2/neu expression in gastric cancer in Bucaramanga metropolitan area between 2006 and 2009. Medicas UIS [online]. 2013, vol.26, n.2, pp.19-28. ISSN 0121-0319.

Introduction: gastric cancer has become a public health problem in the world and in Colombia is one of the leading causes of mortality. The oncoprotein Her/2 neu has shown to be an independent bad prognostic factor with a variable expression ranging from 8 - 91% and has been associated with an aggressive disease and a lesser response to treatment. Aim: to determinate the frequency of Her/2 neu and its expression in gastric carcinoma, also its histopathologic correlation in patients from the Bucaramanga Metropolitan Area during 2006 to 2009. Materials and methods: we conducted an observational cross-sectional study with a population of 409 cases from the Population based Cancer Registry from Bucaramanga Metropolitan Area. The information was collected from clinical history and paraffin blocks. The immunochemistry was made with manual HERCEPTEST method. Scores 0 and 1 were interpretated as negative, score 2 as equivocal and score 3 as positive. The samples that were equivocal underwent fluorescence immunohistochemistry in situ. Results: males predominated with 243 cases, the intestinal type was the more prevalent with 230 cases, Her/2 neu expression was positive in 46 cases and there was no significant statistical association with histopathological subtype or gender. Conclusions: expression of Her/2 neu was positive in 11.2% of gastric carcinomas of patients from Bucaramanga Metropolitan Area, this finding is consistent with other reports, and neither there was any statistical significance association with subtype and gender. (MÉD.UIS.2013;26(2):21-8).

Keywords : Stomach Neoplasms; Receptor, erbB-2; Immunohistochemistry; Prevalence; Colombia.

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