Resumo

ORTIZ-OLVERA, Nayeli X  e  MENDEZ-NAVARRO, Jorge. Prucalopride: selective enterokinetic as a new alternative in the treatment of chronic constipation. Medicas UIS [online]. 2013, vol.26, n.2, pp.27-33. ISSN 0121-0319.

Chronic constipation is a common health problem that affects all ages, generates poor quality of life, and impacts negatively on the health systems of developed and developing countries. The definition of constipation is based on the objectivity of stool frequency as well as in the subjective symptoms associated with this disorder like straining, sensation of incomplete evacuation or hard stools. The treatment includes changes in lifestyle, aerobic exercise, increased intake of water and fiber, laxatives and the use of motility stimulants or prokinetics. A novel alternative is the enterokinetic prucalopride, a selective 5HT4 serotonin agonist, which increases the peristaltic reflex and triggers high amplitude muscle contractions of the colon promoting intestinal deposition. Prucalopride has proven efficacy and safety in adults including elderly patients with chronic constipation. (MÉD.UIS.2013;26(2):29-33)

Palavras-chave : Constipation; Combined Modality Therapy; Gastrointestinal Motility.

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