Resumo

SANTAMARIA-ALZA, Yeison. Phatophysiological Mechanism of the Antiphospholipid Syndrome. Medicas UIS [online]. 2014, vol.27, n.1, pp.43-50. ISSN 0121-0319.

Introduction: the antiphospholipid syndrome is an emerging disease, so there is no real prevalence, however affects approximately 0.5% of the population, mainly women , being a major cause of arterial , venous, or small vessel and obstetric disorders. Objective: to revise to integrate knowledge of the mechanisms involved in pathological pathways involving antiphospholipid antibody syndrome and endogenous substances, to be used in the diagnosis and treatment of this disease. Conclusions: antiphospholipid syndrome involves several components, including the anti - Beta2 - Glicoproteina 1, lupus anticoagulant, anticardiolipin antibodies, anti- serine proteases, antiannexin A5 antibodies, complement system and tissue factor, that doing their actions are causing thrombotic manifestations and obstetric disorders. Understanding the mechanisms of action of these components can contribute to improved diagnostic and therapeutic tool created to reduce mortality and morbidity caused by antiphospholipid syndrome. (MÉD.UIS. 2014;27(1):43-50)

Palavras-chave : Antiphospholipid Antibodies; Thrombosis. Lupus Anticoagulant; Anti-cardiolipin.

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