Abstract

CARVAJAL VALDY, Gabriel. Clinical relevance of peripheral opioid effects. Medicas UIS [online]. 2014, vol.27, n.2, pp.59-65. ISSN 0121-0319.

Although it is a common practice in some centers, there is still little evidence that validates the use of topical analgesic formulations based on opioids for treatment painful skin and mucous conditions. A local focus on the analgesic treatment of painful conditions consists of applying drugs directly in the peripheral site of pain origin. This can be achieved through the topical application of a cream, lotion, gel, spray or patch for somatic sites or through the use of mouthwash in the case of lesions of the oral mucosa. These methods allow a greater local concentration of the drug at the painful site and decrease the systemic levels of the medication to minimum or negligible levels, theoretically reducing the risk of systemic adverse effects. This article aims to review relevant clinical and preclinical information on topical opioid prescribing. (MÉD.UIS. 2014;27:(2)59-65)

Keywords : Analgesics, Opioid; Analgesia; Administration, Topical.

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