Abstract

LLERENA-POLO, Claudia; VALBUENA ARIAS, Angélica  and  ZABALETA-VANEGAS, Angie Paola. Isoniazid and rifampicin resistance in Mycobacterium tuberculosis isolated in patients with coexisting tuberculosis and Human Immunodeficiency Virus, Colombia 2010 - 2012. Medicas UIS [online]. 2016, vol.29, n.2, pp.31-39. ISSN 0121-0319.  https://doi.org/10.18273/revmed.v29n2-2016003.

Introduction: the coexistence of tuberculosis and HIV is a serious public health event that increases the risk of death by 2013 the World Health Organization estimated nine million people with tuberculosis in the world, 1,1 million (13%) would be positive to HIV and of these, 360 000 would die for this cause. Objective: to determine the prevalence of resistance to isoniazid and rifampicin in patients with coexisting tuberculosis and HIV during the years 2010 to 2012. Methods: analysis of a number of cases, which included 902 cases of tuberculosis with coexistence of HIV, the variables of origin, sex, age, sample type and pattern of resistance in new cases were evaluated and previously treated. Results: 78.4% of cases were male, the median age was 34 years multidrug resistance was identified in new cases and 3.6% resistance to isoniazid and rifampicin 6.7% and 1, 4% respectively. In cases previously treated multidrug resistance was 16.2%, resistance to isoniazid and rifampicin 6.3% from 3.7%. Conclusion: it was shown that the presence of drug resistance is higher in previously treated patients; in new cases rifampicin resistance without being multiresistant, something that was not documented in the latest national survey, these findings indicate that it is essential to conduct sensitivity test. MÉD.UIS. 2016;29(2):31-9.

Keywords : Mycobacterium tuberculosis; Tuberculosis; Tuberculosis, Multidrug-Resistance; HIV.

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