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Medicas UIS

Print version ISSN 0121-0319

Abstract

CEBALLOS, Mauricio; GRANADOS, Johan  and  AMARILES, Pedro. Interactions of anti-infectious drugs that trigger renal disease: Approach to establish and assess its clinical relevance. Systematic qualitative review. Medicas UIS [online]. 2017, vol.30, n.3, pp.101-109. ISSN 0121-0319.  http://dx.doi.org/10.18273/revmed.v30n3-2017011.

Introduction:

Drug interactions of anti-infectives can trigger renal disease; however, information on this effect is limited. Therefore, the identification, prevention and management of clinically relevant drug interactions are a key aspect in the achievement of therapeutic objectives in patients receiving anti-infectives.

Objective:

To identify and assess the clinical relevance of anti-infective drug interactions that causes kidney disease.

Methodology:

Systematic qualitative review of drug interactions of anti-infectives associated with renal disease. The clinical relevance of drug interactions was assessed according to the probability of occurrence and severity of the effect. The search was done in the PubMed/Medline database of articles published in english or spanish, between august 2006 and august 2016, using the following Mesh terms and Boolean Operators: “Renal Insufficiency” OR “ Anti-Bacterial Agents “OR” Drug Interactions “OR” HerbDrug Interactions “OR” Food-Drug Interactions “.

Results:

We identified 44 publications and nine were included. In these nine articles, 12 drug interactions associated with renal disease were identified. Combinations associated with renal disease were protease inhibitors/ nifedipine, cobicistat/fenofibrate/pravastatin, tenofovir/metformin, macrolides/statins, statins/calcium channel blockers, quinolones/ warfarin, valaciclovir/loxoprofen and fusidic acid/Pravastatin.

Conclusions:

Protease inhibitors, macrolides and quinolones, as well as tenofovir, cobicistat, valaciclovir and fusidic acid can generate renal disease when used simultaneously with other drugs, especially with statins, calcium channel blockers, warfarin, metformin or loxoprofen. MÉD.UIS. 2017;30(3):101-9

Keywords : Renal Insufficiency; Anti-Infective Agents; Anti-Bacterial Agents; Drug Interactions..

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