Abstract

AUGUSTO URREGO, Jose; OTERO, William  and  TRESPALACIOS, Alba. Advances in the search for the Helicobacter pylori vaccine. Medicas UIS [online]. 2017, vol.30, n.3, pp.111-120. ISSN 0121-0319.  https://doi.org/10.18273/revmed.v30n3-2017012.

Helicobacter pylori is a bacteria that infects the gastric mucosa of around half of the world’s population and it’s implicated in the pathogenesis of various gastric and extragastric diseases in the infected host. Several antigens, adyuvants and routes of immunization have been tested in order to find a vaccine that helps in the control of this bacteria, with varying degrees of success so far, however, sterilizing immunity has been achieved only in animals. Various mechanisms have been proposed to explain the outcomes obtained by testing the potential vaccines and to understand how this bacteria avoids the immunity triggered by itself or by the vaccines tested so far. The current picture does not seem easy but it’s still encouraging since some studies have given hope to the possibility of achieving an effective vaccine. MÉD.UIS. 2017;30(3):111-20.

Keywords : Helicobacter pylori; Vaccination; Antigens; Immunization Stomach Neoplasms; Urease..

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )