Abstract

CORTES, José S et al. Neonatal sepsis: physiopathology and biomarkers. Medicas UIS [online]. 2019, vol.32, n.3, pp.35-47.  Epub Dec 09, 2019. ISSN 0121-0319.  https://doi.org/10.18273/revmed.v32n3-2019005.

Neonatal sepsis is a major cause of morbidity and mortality in newborns worldwide. Its diagnosis remains a challenge due to the nonspecific clinical findings and the lack of efficient diagnostic tools. In the physiopathology of neonatal sepsis, an excessive or suppressed immune response has been described, which can lead to potentially fatal conditions. The prognostic, diagnostic, and follow-up value of several soluble factors altered in neonatal sepsis has been studied. These have been grouped under the term neonatal sepsis biomarkers. Here, aspects of the physiopathology in neonatal sepsis and the characteristics of the most studied biomarkers used for neonatal sepsis diagnosis are described, also, details about other recently studied markers are mentioned. Currently, the use of an early-warning biomarker together with a late-warning biomarker is recommended to get higher diagnostic accuracy. However, a single ideal biomarker for neonatal sepsis has not been found yet. MÉD.UIS.2019;32(3):35-47

Keywords : Newborn; Neonatal sepsis; Interleukin-6; C-reactive protein; Procalcitonin; Biomarkers..

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