Abstract

CASTELLANOS-SUAREZ, Rosendo; SAAVEDRA-GONZALEZ, Karen Yurianny  and  CADENA-MARTINEZ, Andrei Joseph. Update on Vaccination against hepatitis B: special situations and new vaccines. Review article. Medicas UIS [online]. 2024, vol.37, n.1, pp.133-145.  Epub Mar 30, 2024. ISSN 0121-0319.  https://doi.org/10.18273/revmed.v37n1-2024011.

The recombinant DNA vaccine against Hepatitis B virus is the standard vaccine due to its high effectiveness. However, some patients have inadequate responses. This article seeks to describe HBV vaccination in special situations and the development of new vaccines. A search was conducted on PubMed and ScienceDirect using terms such as "Non-responsiveness," "HIV," "renal patients," "dialysis patients," "biological therapy," and "Hepatitis B vaccine," selecting 41 articles for review. In conditions such as HIV infection, chronic kidney disease, biological therapy, and non-responders due to genetic, immunological, and individual variables, there is a greater risk of not generating sufficient antibodies to achieve adequate immunization status. New vaccines (Fendrix®, Heplisav-B®, PreHevbrio®) have been developed which have shown better results, thus necessitating consideration of alternative vaccination approaches in special situations.

Keywords : Hepatitis B Vaccines; Non-responsiveness; HIV; Renal Insufficiency; Chronic; Renal Dialysis; Biological therapy; PreHevbrio^®; Fendrix^®; Heplisav-B^®; Hepatitis B vaccine AS04.

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