Resumo

ZAPATA ZAPATA, CARLOS HUGO  e  BLAIR TRUJILLO, SILVIA. CEREBRAL MALARIA. A REVIEW. Iatreia [online]. 2003, vol.16, n.3, pp.202-216. ISSN 0121-0793.

CEREBRAL MALARIA(CM) is the most common complication of P. falciparum malaria; nearly 90% of people who have suffered CM can recover without neurological problems. Currently there are four hypotheses that explain pathogenesis of CM: cytoadherence and sequestering of parasitized red blood cells to cerebral capillaries; rosette formation and parasitized red blood cells agglutination; production of cytokines and activation of second messengers and opening of the blood-brain barrier. However the main question remains to be answered; how the host-parasite interaction in the vascular space interferes transiently with cerebral function? Recently, the beta amyloid precursor peptide has been employed as marker of neural injury in CM. It is expected that the beta amyloid precursor peptide will help to understand the pathogenesis of CM in complicated patients of endemic areas of Colombia.

Palavras-chave : MALARIA CEREBRAL; COMPLICACIONES; EPIDEMIOLOGÍA; PROTEÍNA BETA-AMILOIDE.

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