Abstract

VELEZ MARIN, VIVIANA MARÍA; PARIS ANGEL, SARA CLAUDIA  and  GARCIA MORENO, LUIS FERNANDO. Interleukin-17: characteristics, differentiation pathways, signaling and biological functions. Iatreia [online]. 2007, vol.20, n.2, pp.186-195. ISSN 0121-0793.

Interleukin-17 is a proinflammatory cytokine with very pleiotropic biological functions. It is secreted by different subsets of activated T cells. Its receptor is found on different cells in a wide range of tissues. IL-17 has been shown to be involved in the development of autoimmune diseases, allograft rejection, cancer, immediate and delayed hypersensitivity responses, and control of infections. IL-17 seems to play an important role in the immune response against Mycobacterium tuberculosis. This review includes the recently elucidated aspects of this cytokine, particularly its molecular characteristics, differentiation pathways, signaling and functions.

Keywords : CYTOKINES; IL-17; IMMUNE RESPO; INFLAMMATION; MYCOBACTERIUM TUBERCULOSIS.

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