SciELO - Scientific Electronic Library Online

vol.21 issue4Epidural analgesia during laborClinical, neuropsychological and sociodemographic characteristics of male children with attention deficit/hyperactivity disorder, with predominance of inattention, in Medellín, Colombia, 2004-2005 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google



Print version ISSN 0121-0793


HERRERA PATINO, Juan Carlos; RAMIREZ GAVIRIA, Gloria Cecilia  and  MUNETON PENA, Carlos Mario. Study of chromosome 17 aneuploidy and of TP53 gene deletion in patients with hematological neoplasias by dualcolor fluorescence in situ hybridization (FISH). Iatreia [online]. 2008, vol.21, n.4, pp.364-374. ISSN 0121-0793.

Hematological neoplasias are characterized by a wide spectrum of genetic alterations. We analyzed 15 specimens from patients with various types of hematological malignancies by means of the FISH technique in order to detect aneuploidy of chromosome 17 and deletion of TP53 gene. In 11 of them chromosomal analyses were also carried out using conventional cytogenetic techniques; in 6 of these 11 specimens (54.5%) abnormal karyotypes were detected, namely: 3 translocations and 3 mosaicisms. FISH results revealed that in 26.7% of the 15 specimens there was chromosome 17 aneuploidy, and that 33.3% had TP53 deletion. Out of the 6 cases with abnormal karyotypes, further alterations were detected in two by FISH. In 5 cases chromosomal abnormalities were detected by FISH but not by the conventional cytogenetic procedures. Only in 3 (20%) out of the 15 specimens the results of chromosomal analyses were normal by both the conventional cytogenetics and FISH. These results corroborate the low frequency of chromosome 17 aneuploidy and of TP53 gene deletion in hematological neoplasias. However, the prognostic value of these genetic alterations is still not well defined.

Keywords : Aneuploidy; Deletion; FISH; Genetic instability; Hematological neoplasias; TP53 gene.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License