versão impressa ISSN 0121-0793
SAAVEDRA RAMIREZ, Publio Giovanni; VASQUEZ DUQUE, Gloria María e GONZALEZ NARANJO, Luis Alonso. Interleukin-6: friend or foe? Basis to understand its utility as a therapeutic target. Iatreia [online]. 2011, vol.24, n.2, pp. 157-166. ISSN 0121-0793.
Cytokines are intercellular communication molecules. They exhibit a great range of actions in different systems and organic processes, notably in the mechanisms that produce the inflammatory response. Interleukin-6 is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory functions. Evidence links this cytokine in an important and direct way with the pathophysiology of diverse autoimmune diseases, in particular, rheumatoid arthritis. This is a review of the molecular basis and the biological effects of interleukin-6. The clinical experience accumulated with therapies that block its pro-inflammatory actions in patients with rheumatoid arthritis are also included.
Palavras-chave : Arthritis Rheumatoid; Autoimmunity; Inflammation; Interleukin-6.