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Iatreia

Print version ISSN 0121-0793

Abstract

ISAZA CORREA, Johana Marcela; VASCO GUTIERREZ, Catalina María  and  VELASQUEZ LOPERA, Margarita María. Arginine and cancer: Implications in the regulation of antitumoral response. Iatreia [online]. 2014, vol.27, n.1, pp.63-72. ISSN 0121-0793.

Recent findings support the potential role of arginine as a regulator of the immune response. Correlation between decreased arginine and decreased proliferation and activation of T lymphocytes has been described in liver transplantation, severe trauma, sepsis and cancer. Among the effects, decrease in the CD3z chain expression (activation signal in the T cell) has been described. Arginine is reduced in relation to the production of arginase 1 (ARG1) by myeloid suppressor cells. Two possible mechanisms have been postulated by which the increased activity of ARG1 could be acting on a tumor. The first is the reduction of lymphocyte proliferation and cell cycle arrest. The second is to promote tumor growth by transforming arginine in precursors of polyamines. We present in this article the main concepts on the role of arginine in antitumor response.

Keywords : Antitumoral Response; Arginase; Arginine; Lymphocytes T; Nitric Oxide Synthase.

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