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Iatreia

Print version ISSN 0121-0793

Abstract

ARCIA ANAYA, David; MONTOYA GUARIN, Carlos Julio  and  RUGELES LOPEZ, María Teresa. Human immunodeficiency virus type 1 (HIV-1) reservoirs: mechanisms of latency and therapeutic strategies Eliuth. Iatreia [online]. 2014, vol.27, n.3, pp.320-329. ISSN 0121-0793.

Human immunodeficiency virus type 1 (HIV-1) can establish a latent infection in different kinds of cells, which constitute the reservoirs for the virus and allow its maintenance in the body indefinitely. The main reservoirs of HIV-1 are resting CD4+ T cells, although other cells, among them monocytes/macrophages, and dendritic cells may also act as such. Different mechanisms contribute to the establishment and maintenance of latency in those cells, among them: transcriptional interference, low availability of transcription factors, chromatin condensation, and some microRNA that block viral translation. Knowledge of these mechanisms is crucial for the development of new drugs that may eliminate the virus from the body and lead to a cure.

Keywords : CD4 T Cells; Dendritic Cells; HIV-1; Latency; Macrophages; Monocytes; Reservoir.

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