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Iatreia

Print version ISSN 0121-0793

Abstract

DUQUE-VELASQUEZ, Camilo et al. Human transmissible spongiform encephalopathy: Case report. Iatreia [online]. 2014, vol.27, n.3, pp.330-336. ISSN 0121-0793.

We report the case of a 64 year-old woman with motor and cognitive deterioration that progressed rapidly during eight months. She was unsuccessfully treated with quinacrine, and died in a terminal status, by septic shock secondary to bronchopneumonia by broncho-aspiration. The brain was donated for research and the histopathological analysis showed spongiform changes, astrogliosis and prion protein (PrPRes) deposits, confirmed by Western blot (WB). These features are considered characteristic of prion diseases, which are uncommon in Colombia. We highlight that its diagnosis was made for the first time in this country by the simultaneous use of immunohistochemistry and Western blot.

Keywords : Creutzfeldt-Jakob Disease; Immunohistochemistry; Prion Diseases; Spongiosis; Western blot.

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