Abstract

DUQUE CARDONA, Leidy Yohana; SOTELO TASCON, Jared  and  VELASQUEZ LOPERA, Margarita María. Key elements of psoriasis immunogenetics. Iatreia [online]. 2014, vol.27, n.4, pp.439-448. ISSN 0121-0793.

Psoriasis is one of the most common skin diseases, affecting 2% to 3% of the world population. It occurs at any stage of life. ''Early'' psoriasis or type I manifests before 40 years, and ''late'' psoriasis or type II, after 40 years. It has a strong genetic basis and the probability of inheriting the disease when both parents are affected is up to 50%. Different susceptibility regions associated with psoriasis, called PSORS, have been described, PSORS-1 being the most frequent one. It is in chromosome 6 and in this region HLA-Cw6 is located, which is until now the gene more associated with psoriasis. The role of HLA-Cw6 in psoriasis is not fully understood, but it has a relationship with type I psoriasis, guttate psoriasis and the presentation of an array of antigens including those derived from Streptococcus pyogenes. Furthermore, some single nucleotide polymorphisms in genes encoding cytokines such as IL-12, IL-23, TNF-α or their receptors are associated with the immunopathogenesis of the disease.

Keywords : Immunogenetics; Interleukin-12; Interleukin-17; Interleukin- 23; Psoriasis.

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