SciELO - Scientific Electronic Library Online

 
vol.30 número3Tamización cardíaca para prevención de muerte súbita en atletas de representación de la Universidad de Antioquia, Medellín, ColombiaEpilepsia y actividad física: conceptos desde la perspectiva de las ciencias básicas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Iatreia

versión impresa ISSN 0121-0793

Resumen

ALVAREZ-BARRENECHE, María Fernanda; VELASQUEZ-FRANCO, Carlos Jaime  y  MESA-NAVAS, Miguel Antonio. Intersticial pulmonary disease in patients with systemic sclerosis. Narrative review of the literatura. Iatreia [online]. 2017, vol.30, n.3, pp.276-286. ISSN 0121-0793.  https://doi.org/10.17533/udea.iatreia.v30n3a03.

Introduction:

Systemic sclerosis is a chronic autoimmune disease, characterized by the triad of small vessel vasculopathy, immune system activation and increased deposits of extracellular matrix in the skin and internal organs. In the last few years, pulmonary involvement has gained relevance since the introduction of angiotensin enzyme converter inhibitors with the subsequent decline in scleroderma renal crisis mortality, transforming scleroderma lung disease in the leading cause of mortality. Pulmonary involvement can manifest as hypertension or interstitial lung disease, which usually occurs in patients with generalized scleroderma in the first three years of the disease. Its prognosis is poor without treatment which is aimed at stopping pulmonary function deterioration. Among treatment options, cyclophosphamide has the best evidence, and mycophenolate mofetil, rituximab, and stem cell and lung transplantation are currently under investigation with positive preliminary results.

Objective:

To describe, according to reports in the literature, epidemiology, pathophysiology, diagnostic methods, and treatment of interstitial lung disease in systemic sclerosis.

Methods:

Structured, non-systematic literature review, focused on the aforementioned aspects of interest. It included 52 articles.

Palabras clave : Bone Marrow Transplantation; Cyclophosphamide; Interstitial Lung Disease; Mycophenolate Mofetil; Rituximab; Systemic Sclerosis; Tomography.

        · resumen en Español | Portugués     · texto en Español     · Español ( pdf )