Abstract

FERREIROS, Alexandra et al. Efficacy of cannabinoids in pharmacoresistant epilepsy: A narrative review of the literature. Iatreia [online]. 2020, vol.33, n.2, pp.167-176. ISSN 0121-0793.  https://doi.org/10.17533/udea.iatreia.42.

Epilepsy is a common neurological disorder that affects approximately 1% of the world’s pop7u-lation. About one third of those patients suffer from treatment-resistant epilepsy (TRE8), defined as failure to stop seizures despite adequate trials of at least two medications at therapeutic dosa-ges. There has been a growing interest in the development of novel antiepileptic drugs with diffe-rent mechanisms of action. This narrative review, based on 42 references retrieved from Scopus and Medline, discusses the scientific data from human and animal studies regarding the efficacy of cannabis-based treatment for epilepsy. Benefits have been described in preclinical and cli-nical studies in children, but ongoing research will clarify the real role of cannabinoids in TRE.

Keywords : Cannabis; Drug Resistant Epilepsy; Review.

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