Abstract

REY, Luz Aída  and  MONTENEGRO, Yenny M.. Myeloid cronic leukemia, state of the art. Rev. Univ. Ind. Santander. Salud [online]. 2009, vol.41, n.2, pp.169-180. ISSN 0121-0807.

Myeloid chronic leukemia is a malignant clonal disorder caused by genetic the translocation t(9; 22) (q34, q11) which generates hyperplasia in bone marrow and uncontrolled myeloid proliferation in peripheral blood. Until 1980, it was considered a fatal disease, however, thanks to scientific progress, scientists began to elucidate different therapeutic strategies, from allogeneic transplantation of bone marrow, to the first and second generation tyrosine kinase inhibitors (Imanitib and Nilotinib), which has provided a positive response in up to 95% of cases. Such development has enforced new diagnostic and monitoring strategies as the fluorescence in situ hybridization and different variants of the polymerase chain reaction. Knowing such advances is fundamental to our performance as health care professionals, allowing us to act and make sound decisions for the benefit of the patient, according to available resources. Salud UIS 2009; 41: 169-180

Keywords : Leukemia myelogenous chronic; BCR-ABL positive; translocation genetic; myeloproliferative syndromes; imatinib.

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