Revista de la Universidad Industrial de Santander. Salud
Print version ISSN 0121-0807
RUEDA, Ernesto; MONTERO, Liliana Patricia and DIAZ, Luis Alfonso. POG 9061 protocol to treat isolated central nervous system recurrence in patients with acute lymphoid leukemia at Hospital Universitario de Santander. Rev. Univ. Ind. Santander. Salud [online]. 2010, vol.42, n.1, pp. 7-17. ISSN 0121-0807.
Introduction: Acute lymphoblastic leukemia (ALL) is the most frequent neoplasm in children. Relapses to central nervous system (CNS) Appears in 5-10 % of the ALL patients and is a bad prognostic factor. Objective: To describe the results obtained with modified POG 9061 protocol in a pediatric oncology unit. Methodology: Survival analysis was made and main complications caused by protocol were analyzed in a retrospective cohort with all of patients attended for ALL with isolated relapse to CNS. Results: Fifteen patients attended from 1993 to 2007 were included; 66.6 % CNS relapses were early to 18 mounts following ALL remission. Two patients left protocol, with one death; there were another two deaths among other patients. Five year global survival rate was 85.6 % (95 %CI 53.3-96.2 %), and event-free survival rate was 84.9 % (95 %CI 51.2-96.0 %). The most frequent complication was mielosupression; renal function alteration was not observed, with a light elevation of hepatic function tests. Infection was the main hospitalization cause. Conclusions: Survival rates and complications (type and frequency) are similar to the other studies. This finding is relevant because half of the patients had early CNS relapse after ALL remission. Salud UIS 2010; 42: 7-17.
Keywords : Lymphoid leukemia; local neoplasm recurrence; vincristine; daunorrubicine.