Abstract

AGUDELO-GOMEZ, Lee Solbay et al. Chemical Composition and evaluation in vitro of anti-herpetic activity of essential oils from Lippia alba (Mill) NE Brown and the main components. Rev. Univ. Ind. Santander. Salud [online]. 2010, vol.42, n.3, pp.230-239. ISSN 0121-0807.

Introduction: Lippia alba (Mill.) N.E. Brown is an aromatic shrub belonging to the Verbenaceae family, which is widely used all over South and Central America as an infusion against, hypertension, digestive troubles, nausea and cold. The antiviral activity in vitro against Herpesvirus 1, Human (HSV-1) of twenty essential oils of L. alba and ten of its components were evaluated. Methodology: The antiviral activity was determined using a modified end-point titration technique (EPPT). The essential oils from L. alba collected in different regions of Colombia were obtained by microwave-assisted hydrodistillation (MWHD). Their chemical compositions were determined by GC and GC/MS. Two chemotypes were distinguished, characterized by carvone and citral as main constituents. Results and conclusions: Carvone chemotype oils BC₁ and CA₂ were found to be moderate antiviral activity over infected confluent monolayers of HeLa cells with Rf value of 1x10^1,5 at a concentration of 250 μg/mL and 125 μg/mL, respectively. Heparin sodium salt and acyclovir were used as positive controls and showed Rf values of 1x10² and 1x10⁴, respectively. None of monoterpenes tested showed antiviral activity against HSV-1. Salud UIS 2010; 42: 230-239

Keywords : Lippia alba (Mill) N.E. Brown; herpesvirus 1 human; essential oil; antiviral agents; verbenaceae.

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