Resumo

MONTIEL RAMOS, Jehidys; MILENA BEDOYA, Astrid; FLOREZ GARCIA, Víctor  e  SANCHEZ VASQUEZ, Gloria I. Variants of Human Papillomavirus 16 and its association with HLA in cervical cancer. Rev. Univ. Ind. Santander. Salud [online]. 2010, vol.42, n.3, pp. 272-280. ISSN 0121-0807.

Cervical cancer is the second most common cancer in women worldwide and the most frequent cancer in women of the majority of developing countries. Persistent infection with Human Papillomavirus (HPV) oncogenic types of HPV is necessary to develop cervical, cancer, with HPV-16 responsible for 50-60% of cases. Non-European variants of HPV-16 have been associated with persistant infection and high degree cervical cancer. Human Leucocyte Antigen (HLA) polymorphisms are also associated with susceptibility to cervical cancer. It has been suggested relationship between HPV-16 variability and some HLA Alleles., This revision refers to the relation between HLA polymorphisms and cervical cancer development, and present evidence that may explain its relation with HPV-16 variability. Salud UIS 2010; 42: 272-280

Palavras-chave : Uterine cervical neoplasm; human leukocyte antigens; human papillomavirus.