Abstract

MENDOZA ROJAS, Víctor Clemente  and  ROA ORTIZ, Melissa Andrea. Hipertiroidismo congénito, Reporte de dos casos. Rev. Univ. Ind. Santander. Salud [online]. 2014, vol.46, n.1, pp.65-70. ISSN 0121-0807.

Introduction: Hyperthyroidism is a thyroidal pathology infrequent in neonates related with maternal history of Graves' disease, and therefore with the transplacental passage of stimulating TSH receptor immunoglobulins. Case report: We report two female gender cases at Hospital Universitario Santander, one of the two cases became manifest during the first week of life, and the other took longer time after the first month of life, as it can happen. Symptoms in common were persistent tachycardia and hyperactivity; one of the cases was mistaken for bacterial infection arising from fever. Diagnose was confirmed of highly suppressed TSH levels and high Free T4, at least twice the limit level. Both cases were treated for some time with antithyroid drugs and ß-blockers, showing good clinical and lab evolution; no complications like arrhythmias or craneosynostosis were observed. Discussion: Congenital hyperthyroidism is a rare condition and should always be suspected in infants of mothers with Graves' disease, its manifestations may occur prenatally or postnatally, and their diagnosis and treatment should be timely to avoid long-term sequelae or death

Keywords : congenital hyperthyroidism; hyperthyroidism in pregnancy; TSH receptor stimulating immunoglobulin; antithyroid drugs.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )