Introduction:

Analogs of the girgensohnine alkaloid, designed and synthesized to inhibit acetylcholinesterase enzyme, have presented an insecticidal effect on vectors insects of diseases.

Objective:

To determine the insecticidal activity of 12 synthetic analogs of gingersohnine in first stage nymphs of Triatoma dimidiata.

Materials and methods:

WHO protocol 2005, using exploratory doses, was used to determine the best molecule according to its mortality. First stage nymphs of T. dimidiata were exposed to different doses of the analogs by topical application and surface exposure. Lethal doses (LD50 and DL95) and alterations in locomotion using Videomex V software were determined.

Results:

Analog 6 presented the highest insecticidal activity at 72 h with a mortality of 20.8% ± 3.57 for topical treatment and 25%±0,0 for non-porous surfaces evaluation. Analog 6 lethal doses were LD50 1036.8 ± 0.38 ng/insecto and DL95 3991.4 ± 0.508 ng/insecto, respectively. With regard to locomotion, analogue 6 induced a similar behavior to that observed for commercial insecticide deltametrin.