Abstract

PLATA S, Laura M; OVIEDO L, Julián F  and  RINCON-OROZCO, Bladimiro. Viral strategies for cancer induction “Epstein-Barr virus: latency and mechanisms associated with viral oncogenesis”. Rev. Univ. Ind. Santander. Salud [online]. 2018, vol.50, n.3, pp.257-268. ISSN 0121-0807.  https://doi.org/10.18273/revsal.v50n3-2018010.

Chronic infection with oncogenic viruses is responsible for approximately 20% of all cancers worldwide in humans, this viral transformation represents a complex, multistage and multifactorial process. An example is the Epstein-Barr virus (EBV), a herpesvirus that latently infects over 90% of the population. Although the infection often courses asymptomatically, EBV is able to modify its genomic expression by establishing different latency phases, thus altering the B lymphocytes and epithelial cells metabolism, a determinant process in the appearance and development of different pathologies ranging from infectious mononucleosis to oncological processes such as Burkitt’s lymphoma, gastric cancer and nasopharyngeal cancer.

Keywords : Epstein-Barr virus; oncogenes; viral proteins; latency; gene expression; herpesvirus.

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