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Revista de la Universidad Industrial de Santander. Salud

Print version ISSN 0121-0807

Abstract

OSORIO-PINZON, Johanna et al. Hormonal, metabolic and hematological profile in adults with the Human Immunodeficiency Virus. Rev. Univ. Ind. Santander. Salud [online]. 2018, vol.50, n.4, pp.296-306. ISSN 0121-0807.  http://dx.doi.org/10.18273/revsal.v50n4-2018003.

Introduction:

Data on the impact of human immunodeficiency virus (HIV) infection on a hormonal, metabolic and haematological level in patients hospitalized in Colombia are scarce.

Objective:

To describe the hormonal, metabolic and haematological profile of HIV patients hospitalized in a third level institution.

Material and method:

Cross-sectional observational study, which included sociodemographic, clinical, hormonal, metabolic and hematological variables of patients with HIV between 2013 and 2014.

Results:

We included 52 patients, 34 men, with an average age of 40 years (SD 12.6, Min: 21 Max: 79). 23% had tuberculosis, 13% had cerebral toxoplasmosis. 26 patients had a history of toxic consumption: cigarette (58%), alcohol (27%) and hallucinogenic substances (15%). 14% of the patients received antiretroviral therapy at admission, mainly with protease inhibitors. Other medications used were: trimethoprim-sulfamethoxazole (27.2%) and antituberculous drugs (15%). The main causes of hospitalization were cerebral toxoplasmosis (31%) and tuberculosis (15%). 52% of the population had Wasting syndrome. The time of diagnosis of HIV was <1 year in 48% of the population. 79% of the patients had a CD4 count <200 cell/mm3 (SD 199, Min: 3 Max: 641). In the hormonal profile, 58% (29 patients) presented alteration of the thyroid axis, of which 14 session profile of central hypothyroidism. 55.8% of men had hyperprolactinemia. The metabolic profile was characterized by hypertriglyceridemia (44%) and low HDL (81%). The most frequent electrolyte alteration was hyponatremia (37%).

Conclusions:

In the population of patients hospitalized with HIV, endocrine alterations were found suggesting primary glandular, pituitary and adrenal involvement, with lipid and electrolyte alterations largely related to advanced disease.

Keywords : Human Immunodeficiency Virus; hormones; metabolic; hospitalization; Colombia.

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