Abstract

CIUODERIS - APONTE, Karl A  and  OCHOA - AMAYA, Julietha E. The Histopathologic -Immunohistochemical presentation of Disseminated Canine Histiocytic Sarcoma. Case report. Orinoquia [online]. 2012, vol.16, n.2, pp.78-87. ISSN 0121-3709.

Disseminated histiocytic sarcoma (DHS), also called malignant histiocytosis is a rare neoplasm in dogs and unknown etiology. It is characterized by malignant neoplastic proliferation of macrophages in various organs and the disseminated form occurs primarily in mononuclear phagocytic system organs like liver, spleen, lymph nodes and small intestine. First reports of DHS are described in Bernese Mountain Dogs, however, has been reported in other breeds such as Rottweilers and Retrievers. There is evidence of the origin of genetic predisposition and DHS in middle-aged dogs, but not limited to these races and may occur sporadically in any race. The DHS commonly originates from the skin and subcutaneous tissue but some cases may originate from deep tissues. The presentation of DHS is difficult to establish because injuries often occur in hidden places and is only recognized after clinical signs appear, among them anorexia, weight loss, lethargy, lymphadenopathy, and hepatosplenomegaly are common, and other signs depend on the organs involved. Histologically DHS is poorly demarcated and cell proliferation results in loss of normal tissue architecture. A mixture predominantly composed of round cells or spindle cells. Many tumors include multinucleated giant cells may be numerous or not. The diagnosis of DHS is based on histopathology and Immunohistochemical. The purpose of this report is to document the case of DHS in a canine female Labrador Retriever, with location on the tongue and oral cavity, appearing as swollen and ulcerated nodular masses multifocal than 1 cm in diameter. Were taken tissue samples and fixed in 10% buffered formalin for routine histopathology. Results included: Areas consist of pleomorphic histiocytic cells supported by connective tissue with abundant eosinophilic cytoplasm with or without small vacuoles and numerous binucleated cells and multinucleated scanty cytoplasm with basophilic pleomorphic nuclei with one or two evident nucleoli, also were observed five to six mitotic figures per field. The specific histologic features of the lesions observed microscopically allowed classify the tumor as disseminated histiocytic sarcoma agreeing with the descriptions given by several authors for DHS in this and other breeds.

Keywords : canine; malignant histiocytocis; mesenchimal neoplasm; round cell tumor.

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