Abstract

MAYORGA-NINO, Fabio  and  TORRES-VIDALES, Giovanny. A review of cannabinoids and endocannabinoids as a tool for developing possible anti-neoplastic agents in dogs: Uma revisão. Orinoquia [online]. 2014, vol.18, n.1, pp.68-78. ISSN 0121-3709.

There are several alternatives for treating malign neoplastic growths in dogs, including chemotherapy; however, traditionally used drugs have high levels of toxicity due to their low selectivity regarding cancer cells. These compounds' main adverse effects involve gastrointestinal disorders, bone marrow suppression (myelotoxicity), behavioral alterations, alopecia and carcinogenic potential. Research groups around the world are currently working on developing new drugs from cannabinoids and/or endocannabinoids-derived molecules, based on tetrahydrocannabinol and anandamide's known anti-neoplastic activity. Trials reported to date have led to concluding that such compounds offer greater selectivity regarding action on unhealthy cells, thereby representing a lower range of toxic risks. It has been shown that pharmacological treatment regarding any disease should adhere to biological rhythms to obtain a better therapeutic response and incur fewer collateral effects. This article was thus aimed at ascertaining the benefits of future antineoplastic treatment inspired by the behavior of cannabinoids and endocannabinoids in the evolution of neoplastic diseases.

Keywords : Neoplastic growth; cannabinoid; endocannabinoid; chronopharmacology.

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