Abstract

EDITION BY APOBEC, A NEW RESISTANCE MECHANISM TO HIV-1 INFECTION. Vitae [online]. 2008, vol.15, n.1, pp.183-193. ISSN 0121-4004.

HIV/AIDS affects more of 40 million people in the world. The high costs of the antiretroviral compounds, and the resistance to these medicines has led to intense search for new antiviral, focused on substances to be actives white proteins or other molecules that participates in the virus's cycle, in order to increase the survival and the quality of life of infected patients. Recently, certain cellular factors were described by their anti-HIV- 1 activity. According to their characteristics, they constitute a family of cellular proteins known as APOBEC. The members of this family are deaminases enzymes that modify cytosine to uracilo in cellular or foreign DNA/RNA. The sub-family APOBEC 3 is the most intensely studied, since some of they members exhibited antiviral activity against viruses such as HIV-1. APOBEC3, not only after edition of the viral genome, but with the blockaded of it's replication in different stages of his cycle. This review attempts to analyse the APOBEC family of proteins to understand the mechanisms by which they offer resistance to certain viruses particularly to HIV-1, where still more studies need to be performed to understand how this virus partially or completely escapes inhibition by these proteins.

Keywords : Resistance; Cellular deaminases; APOBEC3G; hA3G; HIV-1.

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