Servicios Personalizados
Revista
Articulo
Indicadores
- Citado por SciELO
- Accesos
Links relacionados
- Citado por Google
- Similares en SciELO
- Similares en Google
Compartir
Vitae
versión impresa ISSN 0121-4004
Resumen
FLOREZ A, Oscar A; TOBON Z, Gloria E y LOPERA G, Erika M. KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE. Vitae [online]. 2009, vol.16, n.3, pp.354-360. ISSN 0121-4004.
The activation energy variation can be used as a quick measure to differentiate polymorphs of active pharmaceutical ingredients. In this paper diverse phenytoin crystal habits have been obtained through processes of recrystallization in different solvents. Some of these solids differ in melting point by DSC, but are similar in XRD and FT-IR. From the results of melting point, 4 solids are selected by presenting the most dissimilar values. Their activation energy (Ea) is determined by DSC technique, using 3 theoretical isoconversional nonisothermal models and it is found even that 23 Kcal/ mol of difference separate the most extreme values.
Palabras clave : pseudopolymorphs; activation energy; recrystallization.