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Vitae
Print version ISSN 0121-4004
Abstract
BORDA, David Camilo and GUERRERO, Mario Francisco. Effect of a diet rich in potato peel on platelet aggregation. Vitae [online]. 2024, vol.31, n.1, a349415. Epub Nov 19, 2024. ISSN 0121-4004. https://doi.org/10.17533/udea.vitae.v31n1a349415.
Background:
Potato peel extract has demonstrated the ability to reduce platelet aggregation in vitro, suggesting its potential as a dietary intervention for preventing atherothrombotic disorders.
Objective:
This study aims to evaluate the impact of a potato peel-rich diet on platelet aggregation.
Methods:
A randomized, crossover-controlled, open two-period study was carried out with the participation of 12 healthy volunteers. Platelet aggregation was assessed before and after a seven-day dietary intervention. Participants consumed either a diet rich in potato peel (2 g/kg/d) or acetylsalicylic acid (ASA) as a reference (100 mg/d). Platelet aggregation percentages were measured following stimulation with arachidonic acid (AA, 150 µg/mL), adenosine diphosphate (ADP, 10 µM), and collagen (COL, 10 µg/mL).
Results:
The potato peel-rich diet resulted in a slight but significant reduction in platelet aggregation when stimulated with arachidonic acid compared to baseline values (85.0±2.0% vs. 91.3±1.7%, p<0.05). This effect was less pronounced than the reduction achieved with ASA (16±1.9%, p<0.001).
Conclusion:
The administration of a diet rich in potato peel reduces platelet aggregation induced by arachidonic acid, suggesting its potential role in the prevention of atherothrombotic disorders.
Keywords : Solanum tuberosum; Potato; Platelet aggregation; Caffeic acid; Chlorogenic acid.