Abstract

DE OLIVEIRA, Adriana Cristina; OLIVEIRA DE PAULA, Adriana  and  FARNETANO ROCHA, Rodrigo. Costs of antimicrobial treatment in patients with infection. av.enferm. [online]. 2015, vol.33, n.3, pp.352-361. ISSN 0121-4500.  https://doi.org/10.15446/av.enferm.v33n3.37356.

Introduction: Costs related to antimicrobial treatment of patients with bloodstream infections caused by resistant microorganisms have been little explored. Objective: Compare the cost of treatment in patients with oxacillin-resistant Staphylococcus aureus (MRSA) and oxacillin-susceptible Staphylococcus aureus (MSSA) bloodstream infection (BSI). Methodology: It is a historic cohort study performed in an intensive care unit with patients with Staphylococcus aureus bsi between March/2007 and March/2011. Patients’ medical records, records of the hospital infection control committee and of the hospital financial system were used. Univariate analysis were performed. Results: 31 patients with MRSA and MSSA infection took part in the study. According to the univariate analysis, directed therapy lowered the spectrum of antibiotics activity and the costs (p = 0,000), bacterial resistance was linked to a bigger expenditure in empiric antimicrobial therapy (p = 0,013), not being found any association for directed or total therapy. Conclusion: Bacterial resistance may influence the costs of antimicrobial therapy. More studies are needed, specifically, evaluating antibacterial therapy.

Keywords : Drug Resistance; Drug Costs; Bacterial Infections; Nursing.

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