Objective:

To verify potentially theoretical drug interactions (PTDI), including their clinical repercussions, and correlate them to the clinical-pharmacological profile of medical prescriptions in the postoperative period of cardiac surgery.

Materials and Method:

Descriptive, cross-sectional, and retrospective study with a sample of 133 drug prescriptions of hospitalized patients in a Rio de Janeiro state hospital in Brazil, between March and August 2018. To assess the interactions, the Micromedex Solutions® Software was used, followed by the descriptive and inferential statistics of the data by the Epi Info 7® Software.

Results:

A total of 2,062 doses were prescribed, identifying 96 PTDI, of which 66 were classified as severe and 30 as moderate. The most prevalent PTDI was Bromopride/Tramal® intravenously (n = 26), followed by ASA/Clopidogrel (n = 21) orally. There was an association between the variables drug interaction-polypharmacy (x2 = 98,853, p = 0.0000001) and drug interaction-comorbidities (x 2 = 4,246, p = 0.23609658).

Conclusions:

A high prevalence of PTDI during the postoperative period of cardiac surgery was reported. The early verification of prescriptions makes it possible to detect and adopt mitigation measures in response to medication errors, thus contributing to patient safety and higher quality in the care provided.

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