Abstract

CHAPARRO, ORLANDO  and  BELTRAN, ORIETTA. NUCLEAR REPROGRAMMING AND INDUCED PLURIPOTENT CELLS. rev.fac.med [online]. 2009, vol.17, n.2, pp. 252-263. ISSN 0121-5256.

Reprogramming of somatic cells to generate induced pluripotent stem cells (iPS), has been one of the most important advances in biology in recent years. The identification of a group of transcription factors and more recently of some chemical compounds that can induce pluripotency in somatic cells provides a unique opportunity to study cellular and molecular mechanisms of cell differentiation and promises the possibility of generating patient-specific pluripotent stem cells for the treatment of multiple diseases in protocols of cell therapy and regenerative medicine.

Keywords : nuclear reprogramming; pluripotency; reprogramming factors; Induced pluripotent Stem Cells (iPS).