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Revista Med
Print version ISSN 0121-5256On-line version ISSN 1909-7700
Abstract
CHAPARRO, ORLANDO and BELTRAN, ORIETTA. NUCLEAR REPROGRAMMING AND INDUCED PLURIPOTENT CELLS. rev.fac.med [online]. 2009, vol.17, n.2, pp.252-263. ISSN 0121-5256.
Reprogramming of somatic cells to generate induced pluripotent stem cells (iPS), has been one of the most important advances in biology in recent years. The identification of a group of transcription factors and more recently of some chemical compounds that can induce pluripotency in somatic cells provides a unique opportunity to study cellular and molecular mechanisms of cell differentiation and promises the possibility of generating patient-specific pluripotent stem cells for the treatment of multiple diseases in protocols of cell therapy and regenerative medicine.
Keywords : nuclear reprogramming; pluripotency; reprogramming factors; Induced pluripotent Stem Cells (iPS).