Abstract

RODRIGUEZ ESTUPINAN, ESTABAN CAMILO et al. HISTOLOGICAL ANALYSIS OF IMPLANTED PORUS CARBONATED APATITE OF DRY SYNTHESIS EMBEDDED WITH PORCINE BONE MARROW CELLS. rev.fac.med [online]. 2010, vol.18, n.1, pp.32-43. ISSN 0121-5256.

Carbonated apatite (CAp) constitutes one of the principal inorganic components of the osseous tissue. After synthetising of CAp by reaction of the solid state, the ceramic was treated with porcine bone marrow progenitors and then implanted subcutaneously and in created osseous defects. This article shows the description and analysis of histological samples. Results indicated that the material does not generate rejection; it is re-absorbed by the recipient's osteoclasts activity and then is replaced by biologically synthesised bone. Membranous ossification is described to be responsible for the regeneration of osseous tissue in artificially created defects, with or without being filled with CAp. The quantitative differences between controls and treatments in respect of the total area covered by the material indicate its high biodegradability, probably due to a major osteoclastic activity and/or an improved assimilative response, given the presence of potentially osteogenic cells of the own individual. This hypothesis is reinforced by the observation of more blood vessels in subcutaneous implants previously treated with bone marrow cells. According to the evaluated criteria, porous CAp of dry synthesis shows excellent biocompatibility, osteoinductivity and osteoconductivity, characteristics that are promoted when the material is pre-treated with osteoprogenitors from the bone marrow.

Keywords : solid state reaction; carbonated apatite; osteoprogenitor cells; bone substitutes.

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