Resumo

GUZMAN V., CLAUDIA M. et al. INCLUSION BODY MYOPATHY: CASE REPORT AND LITERATURE REVIEW. rev.fac.med [online]. 2010, vol.18, n.1, pp.93-99. ISSN 0121-5256.

Inclusion body myositis (IBM) is an infrequent disease in people over 50 years of age, affecting more frequently males; however the symptoms may begin 20 years before its diagnosis. Up to 30% of all inflammatory myopathies can be IBM and its prevalence varies among different countries and ethnical groups. IBM manifest clinically by slowly progressive proximal and distal weakness. In this article a report of case is presented: A female patient 78 years old with previous history of type 2 diabetes mellitus, hypertension and hypothyroidism; with 18 months history of weakness in lower limbs, inability to climb stairs, limited to walk, associated with dysesthesias. The initial CK was 7820 mg/dl, the electromyography and nerve conductions reported a motor axonal polyneuropathy of four limbs and inflammatory myopathy. She was treated with steroids at doses of 1mg/kg without improvement, after 6 months of treatment. It was decided to take a muscle biopsy that showed an inclusion body myopathy, explaining the initial treatment failure. This case is interesting from a clinical point of view, since it is not frequent elevated CK levels as it was presented by the patient and for the numerous associated co-morbidities.

Palavras-chave : myositis; myopathy; inclusion bodies.

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