Resumo

SERRANO DIAZ, NORMA CECILIA et al. THE ROLE OF LIPID FRACTIONS, LIPOPROTEINS AND APOLIPOPROTEINS IN PREECLAMPSIA. rev.fac.med [online]. 2012, vol.20, n.1, pp.62-73. ISSN 0121-5256.

Preeclampsia (PE) is a multisystemic disorder unique to human pregnancy and responsible for about 44,000 maternal deaths worldwide. This disease is associated with multiple complications for both mother and fetus; however, its etiology is not totally clear and it has therefore been difficult to define valid prediction strategies. PE is a complex disease and it shares different risk factors with cardiovascular disease, such as obesity, hypertension, insulin resistance and dyslipidemia, evidencing that the presence of disturbances in lipid and apolipoprotein levels are associated with increased lipid peroxidation and oxidative stress which can lead to endothelial dysfunction in both diseases. Therefore, exploring the evidence of an association between lipid fractions and PE risk can provide new knowledge about the etiology of this disease. In this review, the major biological implications of lipid profile and apolipoproteins alterations in the genesis of PE will be presented, describing the observational studies and identifying its main methodological weaknesses in order to create strategies for comprehensive assessment of the pathophysiological pathway with potential predictive implications of the disease.

Palavras-chave : Preeclampsia; Dyslipidemias; apolipoproteins; lipid peroxidation; Mendelian Randomization Analysis.

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