Abstract

MUNAR, MARÍA ANGÉLICA et al. TERAPIA BIOLÓGICA EN PATOLOGÍA PULMONAR: PARTE I: GENERALIDADES Y CLASIFICACIÓN PARTE II: TERAPIAS ESPECÍFICAS EN ASMA, EPOC, ENFERMEDAD PULMONAR PARINQUEMATOSA DIFUSA, CÁNCER PULMONAR. rev.fac.med [online]. 2012, vol.20, n.2, pp.82-100. ISSN 0121-5256.

The advancement of medical research in molecular biology and genetic engineering has given rise to the development of new drugs aimed at blocking different pathways of cellular immune responses. Biological therapy is a new therapeutic option for progressive chronic disease management. In chronic lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), diffuse parenchymal lung disease (DPLD) and lung cancer, treatment with biologics has made important advances in the understanding of these diseases, and in some cases, due to their effectiveness, has contributed to the improvement in life quality of patients who suffer them. Due to the increasing number of biological therapy drugs and their therapeutic application in chronic inflammatory diseases and cancer, it is relevant to review their current status in the management of chronic lung diseases.

Keywords : Biological agents; monoclonal antibodies; immunotherapy; immunomodulation; mechanism of action; antigen presentation; asthma; chronic obstructive pulmonary disease (COPD); diffuse parenchymal lung disease (DPLD); lung cancer.

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