Abstract

NARVAEZ-PARDO, Jorge Andrés; VILLARREAL CAMACHO, José-Luis; VARELA PRIETO, Lourdes Luz  and  CERVANTES-ACOSTA, Guillermo. C-terminal Motifs of HIV-1 gp41 as Possible Determinants of Viral Pathogenesis. Rev. Med [online]. 2021, vol.29, n.2, pp.107-120.  Epub Aug 01, 2022. ISSN 0121-5256.  https://doi.org/10.18359/rmed.5850.

human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS), a pandemic with high economic and social costs. The envelope glycoprotein (ENV) of the virus mediates the infectious process by binding to and entering the host cell, one of the main target components of studies since its discovery. Its endodomain or C-terminal tail (CTT) participates in late replicative cycle processes, such as intracellular trafficking, activation, and cell death, which occurs because it interacts with multiple cellular factors through motifs or signal sequences present throughout its structure. Although these interactions have not been fully understood at specific levels, studies over more than three decades leave no doubtthatthis domain plays a fundamental role in the biology of the virus and probably the development of the disease. This review describes the studies carried out to date that demonstrate the importance of the CTT, focusing on the motifs responsible for its interactions and its possible roles in the pathogenicity of the infection.

Keywords : HIV-1; envelope glycoprotein; gp41; C-terminal tail; motifs; pathogenicity; AIDS.

        · abstract in Spanish | Portuguese     · text in English     · English ( pdf )