Resumo

YASSIN, Lina María; GARCIA, Luis Fernando; ROJAS, Mauricio  e  VASQUEZ, Gloria. Failure in the apoptotic cells clearance, a source of autoantigens . Rev.Colomb.Reumatol. [online]. 2006, vol.13, n.1, pp.76-84. ISSN 0121-8123.

Apoptosis is a critical process to controll proliferation and cell number. Deficiencies in apoptosis/survival balance takes to diseases such as cancer and autoimmunity. Apoptotic cells express phosphatidylserine (PS), at membrane surface and some other molecules, which are important for its recognizing by “scavenger” receptors expressed by professional and not professional phagocytes and posterior clearance. Disturbances in apoptotic cells removal is a common characteristic in autoimmune diseases like Systemic Lupus Erythematosus and one of the reasons could be the defects in “Scavenger” receptors. The aim of this review is to expose the importance of apoptotic cells clearance for the development of several diseases such as autoimmune ones.

Palavras-chave : apoptosis; “Scavenger” receptors; clearance; phagocytosis.

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