Resumen

VARGAS GRAJALES, Francisco et al. Antiphospholipid syndrome: Morbidity and evolution of a cohort of patients of Hospital Pablo Tobón Uribe of Medellín-Colombia. Rev.Colomb.Reumatol. [online]. 2006, vol.13, n.2, pp.109-119. ISSN 0121-8123.

Objetive: describe the clinical and laboratory characteristics in a cohort of patient with SAF and explore possible association between autoantibodies and clinical complications. Methods: this assay have been based in analytic study of transversal cohort in patients with a criterion of Sapporo of SAF. Results: a total of 62 patients are described, with a 83.9% of women and 16.1% of men. The patients were 28 years old at inclusion. The primary anthiphospholipid syndrome (PAPS) was observed in 32.3% of patients and the secondary anthiphospholipid syndrome (SAPS) were found in the 67.7% of patients. The patients with PAPS were older and have more fetal looses than SAPS. The risk of recurrence venous thrombosis was major than arterial thrombosis. Conclusions: anthiphospholipid syndrome have a big spectrum of clinicals manifestation afecting any organ. The association with autoinmune disease can create subgroups of this disease. Some differences were found between SAPS and PAPS in prognosis and clinical compromise.

Palabras clave : anthiphospholipid syndrome; antibodies anticardiolipin; lupus coagulation inhibitor.

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