Revista Colombiana de Reumatología
versão impressa ISSN 0121-8123
ROMERO-SANCHEZ, C et al. New paradigm in spondyloarthritis: Lymphocytes Th-17. Rev.Colomb.Reumatol. [online]. 2010, vol.17, n.1, pp. 48-57. ISSN 0121-8123.
Spondyloarthritides are a heterogeneous group of diseases which are mainly associated with HLA B 27 and environmental factors. The evidence for these disorders reflects an adaptive immune system-mediated autoimmune origin where inflammatory lesion composition is mainly represented by activated macrophages, B lymphocytes and T lymphocytes. These T-cells phenotype and nature has not been well established. Recent studies have shown that the classical CD4+ Th-1/Th-2 effector-cell model should be reevaluated and Th-17 cells should be introduced in inflammatory joint pathogenesis. Preliminary studies have directed research towards the IL-23/IL-17 axis in spondyloarthropathies as a new proposal. The intervention of the molecules involved in this pathway might be interesting as new therapeutic targets.
Palavras-chave : lymphocyte Th-17; IL-17; IL-23; spondyloarthritis; arthritis induced; inflammation.